a primitive root; to mope, i.e. (figuratively) pine; sorrow.
Usages throughout the bible
Leviticus 26:16
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I also will do this unto you; I will even appoint over you terror, consumption, and the burning ague, that shall consume the eyes, and cause sorrow H1727 of heart: and ye shall sow your seed in vain, for your enemies shall eat it.